702681-67-2

702681-67-2 structure

Name: CP-868388 free base
Chemical Name: (S)-3-[3-(1-carboxy-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid 4-isopropyl-benzyl ester
CAS Number: 702681-67-2
Molecular Formula: C₂₆H₃₃NO₅
Molecular Weight: 439.54400
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2016-02-25 14:22:01
Modify Date: 2024-01-12 10:13:54
CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions[1].

Name	(S)-3-[3-(1-carboxy-1-methyl-ethoxy)-phenyl]-piperidine-1-carboxylic acid 4-isopropyl-benzyl ester

Description	CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	hPPARα:10.8 nM (Ki) hPPARγ:3.47 μM (Ki)
In Vitro	CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC50 of 4.7 nM) and PGC-1α peptide[1]. CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC50 of 18 nM in HepG2 cells[1].
In Vivo	CP-868388 (0-3 mg/kg; oral gavage; once daily; for 2 days; male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%[1]. Animal Model: Male B6/CBF1J mice[1] Dosage: 0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration: Oral gavage; once daily; for 2 days Result: Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.
References	[1]. Christopher D Kane, et al. Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. Mol Pharmacol. 2009 Feb;75(2):296-306.

Molecular Formula	C₂₆H₃₃NO₅
Molecular Weight	439.54400
Exact Mass	439.23600
PSA	76.07000
LogP	5.50610

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310-P501
RIDADR	UN 2811 6.1 / PGIII

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