Methyltetrazine-PEG5-alkyne

Modify Date: 2024-01-08 19:26:20

Methyltetrazine-PEG5-alkyne Structure
Methyltetrazine-PEG5-alkyne structure
Common Name Methyltetrazine-PEG5-alkyne
CAS Number 1802907-97-6 Molecular Weight 402.444
Density 1.2±0.1 g/cm3 Boiling Point 568.5±60.0 °C at 760 mmHg
Molecular Formula C20H26N4O5 Melting Point N/A
MSDS N/A Flash Point 198.5±23.1 °C

 Use of Methyltetrazine-PEG5-alkyne


Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Methyltetrazine-PEG5-Alkyne
Synonym More Synonyms

 Methyltetrazine-PEG5-alkyne Biological Activity

Description Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 568.5±60.0 °C at 760 mmHg
Molecular Formula C20H26N4O5
Molecular Weight 402.444
Flash Point 198.5±23.1 °C
Exact Mass 402.190308
LogP 0.04
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.531

 Synonyms

1,2,4,5-Tetrazine, 3-methyl-6-[4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)phenyl]-
3-Methyl-6-[4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)phenyl]-1,2,4,5-tetrazine
MFCD28334550