Bromoacetamido-PEG4-acid
Modify Date: 2024-01-06 09:16:17
Bromoacetamido-PEG4-acid structure
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Common Name | Bromoacetamido-PEG4-acid | ||
|---|---|---|---|---|
| CAS Number | 1807518-67-7 | Molecular Weight | 386.236 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 557.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C13H24BrNO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 291.1±30.1 °C | |
Use of Bromoacetamido-PEG4-acidBromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | 1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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| Related Catalog | |
| Target |
PEGs Cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 557.7±50.0 °C at 760 mmHg |
| Molecular Formula | C13H24BrNO7 |
| Molecular Weight | 386.236 |
| Flash Point | 291.1±30.1 °C |
| Exact Mass | 385.073608 |
| LogP | -1.31 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.494 |
| Hazard Codes | Xi |
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| 1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid |
| 6,9,12,15-Tetraoxa-3-azaoctadecan-18-oic acid, 1-bromo-2-oxo- |
| MFCD28950779 |