Methylamino-PEG1-Boc

Modify Date: 2024-01-10 21:48:42

Methylamino-PEG1-Boc Structure
Methylamino-PEG1-Boc structure
Common Name Methylamino-PEG1-Boc
CAS Number 1807521-03-4 Molecular Weight 203.279
Density 1.0±0.1 g/cm3 Boiling Point 266.7±15.0 °C at 760 mmHg
Molecular Formula C10H21NO3 Melting Point N/A
MSDS N/A Flash Point 115.1±20.4 °C

 Use of Methylamino-PEG1-Boc


Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Methylamino-PEG1-t-butyl ester
Synonym More Synonyms

 Methylamino-PEG1-Boc Biological Activity

Description Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 266.7±15.0 °C at 760 mmHg
Molecular Formula C10H21NO3
Molecular Weight 203.279
Flash Point 115.1±20.4 °C
Exact Mass 203.152145
LogP 1.15
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.436

 Synonyms

Propanoic acid, 3-[2-(methylamino)ethoxy]-, 1,1-dimethylethyl ester
MFCD28155197
2-Methyl-2-propanyl 3-[2-(methylamino)ethoxy]propanoate