Mal-PEG1-Boc

Modify Date: 2024-02-01 12:13:09

Mal-PEG1-Boc Structure
Mal-PEG1-Boc structure
Common Name Mal-PEG1-Boc
CAS Number 810677-16-8 Molecular Weight 269.294
Density 1.2±0.1 g/cm3 Boiling Point 390.5±22.0 °C at 760 mmHg
Molecular Formula C13H19NO5 Melting Point N/A
MSDS N/A Flash Point 190.0±22.3 °C

 Use of Mal-PEG1-Boc


Mal-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-PEG1-t-butyl ester
Synonym More Synonyms

 Mal-PEG1-Boc Biological Activity

Description Mal-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 390.5±22.0 °C at 760 mmHg
Molecular Formula C13H19NO5
Molecular Weight 269.294
Flash Point 190.0±22.3 °C
Exact Mass 269.126312
LogP 1.32
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.498

 Synonyms

MFCD28142478
2-Methyl-2-propanyl 3-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]propanoate
Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 1,1-dimethylethyl ester
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