3,4-Dibromo-Mal-PEG2-Amine TFA

Modify Date: 2024-01-09 21:58:45

3,4-Dibromo-Mal-PEG2-Amine TFA Structure
3,4-Dibromo-Mal-PEG2-Amine TFA structure
Common Name 3,4-Dibromo-Mal-PEG2-Amine TFA
CAS Number 1807534-86-6 Molecular Weight 386.037
Density 1.8±0.1 g/cm3 Boiling Point 425.1±45.0 °C at 760 mmHg
Molecular Formula C10H14Br2N2O4 Melting Point N/A
MSDS N/A Flash Point 210.9±28.7 °C

 Use of 3,4-Dibromo-Mal-PEG2-Amine TFA


3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3,4-Dibromo-Mal-PEG2-Amine
Synonym More Synonyms

 3,4-Dibromo-Mal-PEG2-Amine TFA Biological Activity

Description 3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 425.1±45.0 °C at 760 mmHg
Molecular Formula C10H14Br2N2O4
Molecular Weight 386.037
Flash Point 210.9±28.7 °C
Exact Mass 383.932007
LogP -0.21
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.602

 Synonyms

1H-Pyrrole-2,5-dione, 1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-3,4-dibromo-
1-{2-[2-(2-Aminoethoxy)ethoxy]ethyl}-3,4-dibromo-1H-pyrrole-2,5-dione
MFCD27635180
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