Fluorescein isothiocyanate (Spiro Form)

Modify Date: 2024-01-02 18:23:47

Fluorescein isothiocyanate (Spiro Form) Structure
Fluorescein isothiocyanate (Spiro Form) structure
 Common Name Fluorescein isothiocyanate (Spiro Form)
CAS Number 18861-78-4 Molecular Weight 389.381
Density 1.5±0.1 g/cm3 Boiling Point 719.1±60.0 °C at 760 mmHg
Molecular Formula C21H11NO5S Melting Point N/A
MSDS N/A Flash Point 388.7±32.9 °C

 Use of Fluorescein isothiocyanate (Spiro Form)


Fluorescein-6-isothiocyanate is a fluorescent isomeric haptenic probes with Kds of 8.74, 2.72 and 1.88 for N-Acetyl-L-Lysine, normal mouse IgG and 4-4-20, respectively[1].

 Names

Name 3',6'-dihydroxy-5-isothiocyanatospiro[2-benzofuran-3,9'-xanthene]-1-one
Synonym More Synonyms

 Fluorescein isothiocyanate (Spiro Form) Biological Activity

Description Fluorescein-6-isothiocyanate is a fluorescent isomeric haptenic probes with Kds of 8.74, 2.72 and 1.88 for N-Acetyl-L-Lysine, normal mouse IgG and 4-4-20, respectively[1].
Related Catalog
Target

Kd: 8.74 (N-Acetyl-L-Lysine), 2.72 (normal mouse IgG), 1.88 (4-4-20)[1]

References

[1]. Swindlehurst CA, et al. Fluorescence measurements of immune complexes of Mab 4-4-20 with isomeric haptens. Biophys J. 1991 Mar;59(3):619-28.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 719.1±60.0 °C at 760 mmHg
Molecular Formula C21H11NO5S
Molecular Weight 389.381
Flash Point 388.7±32.9 °C
Exact Mass 389.035797
PSA 120.44000
LogP 4.00
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.754

 Safety Information

HS Code 2932999099

 Synthetic Route

Thiophosgene structure

Thiophosgene

CAS#:463-71-8

6-Aminofluorescein structure

6-Aminofluorescein

CAS#:51649-83-3

~%

Fluorescein isothiocyanate (Spiro Form) Structure

Fluorescein iso...

CAS#:18861-78-4

Literature: Tomasch, Miriam; Schwed, J. Stephan; Kuczka, Karina; Meyer Dos Santos, Sascha; Harder, Sebastian; Nuesing, Rolf M.; Paulke, Alexander; Stark, Holger ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 9 p. 774 - 779
Resorcine structure

Resorcine

CAS#:108-46-3

~%

Fluorescein isothiocyanate (Spiro Form) Structure

Fluorescein iso...

CAS#:18861-78-4

Literature: ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 774 - 779
6-Nitrofluorescein (isomer II) structure

6-Nitrofluoresc...

CAS#:27402-68-2

~%

Fluorescein isothiocyanate (Spiro Form) Structure

Fluorescein iso...

CAS#:18861-78-4

Literature: ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 774 - 779
4-Nitrophthalic acid structure

4-Nitrophthalic acid

CAS#:610-27-5

~%

Fluorescein isothiocyanate (Spiro Form) Structure

Fluorescein iso...

CAS#:18861-78-4

Literature: ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 774 - 779
3',6'-Bis(acetyloxy)-6-nitrospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one structure

3',6'-Bis(acety...

CAS#:53299-21-1

~%

Fluorescein isothiocyanate (Spiro Form) Structure

Fluorescein iso...

CAS#:18861-78-4

Literature: ACS Medicinal Chemistry Letters, , vol. 3, # 9 p. 774 - 779

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Fluorescein isothiocyanate
Fluorescein-6-isothiocyanate
6-FITC (isomer II)
6-FITC
6-Isothiocyanatofluorescein
6-Isothiocyanatofluorescein (isomer II)
FITC 'Isomer II'
fluorescein 6-isothiocyanate
Fluorescein 6-Isothiocyanate (isoMer II)
FITC
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3',6'-dihydroxy-6-isothiocyanato-
Fluorescein Isothiocyanate (isomer II)
fluorescein-5-isothiocyanate
FITC isomer II [Fluorescein-6-isothiocyanate]
3',6'-Dihydroxy-6-isothiocyanato-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
F6ITC
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