[DPro5] Corticotropin Releasing Factor, human, rat

Modify Date: 2024-04-03 15:15:37

[DPro5] Corticotropin Releasing Factor, human, rat structure	Common Name	[DPro5] Corticotropin Releasing Factor, human, rat
	CAS Number	195628-97-8	Molecular Weight	4757.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀₈H₃₄₄N₆₀O₆₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [DPro5] Corticotropin Releasing Factor, human, rat

[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1].

Name	[DPro5] Corticotropin Releasing Factor, human, rat

Description	[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> CRFR
In Vitro	[DPro5] Corticotropin Releasing Factor, human, rat (1 nM; 1 h) diminishes the amplitude of hippocampal population spike and prevents the onset of long-term potentiation (LTP)[2].
In Vivo	[DPro5] Corticotropin Releasing Factor, human, rat (0.01-1 μg; i.c.v.; single dose) doesn’t induce the typical anxiogenic effect, but produces a nonspecific suppression of behavior in Sprague-Dowley rats. And [DPro5] Corticotropin Releasing Factor, human, rat also enhances the short-term memory to a maximum degree and prevented the memory loss induced by diazepam[1]. Animal Model: Sprague-Dowley rats[1] Dosage: 0.01-1 μg Administration: Intracerebroventricular injection; single dose Result: Decreased the number of visits into the light box in the dark-light test.
References	[1]. Shabanov PD, et al. [Anxiogenic and mnestic effects of corticoliberin and its analogs introduced into the brain ventriculi of rats]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):3-8. Russian. [2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7.

Molecular Formula	C₂₀₈H₃₄₄N₆₀O₆₃S₂
Molecular Weight	4757.45

[DPro5] Corticotropin Releasing Factor, human, rat

Use of [DPro5] Corticotropin Releasing Factor, human, rat

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Chemical & Physical Properties