[Tyr0] Corticotropin Releasing Factor, ovine
![[Tyr0] Corticotropin Releasing Factor, ovine Structure](https://image.chemsrc.com/caspic/423/83930-34-1.png)
[Tyr0] Corticotropin Releasing Factor, ovine structure
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Common Name | [Tyr0] Corticotropin Releasing Factor, ovine | ||
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| CAS Number | 83930-34-1 | Molecular Weight | 4833.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C214H348N60O65S1 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of [Tyr0] Corticotropin Releasing Factor, ovine[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin[1][2]. |
| Name | Tyr-CRF (ovine) |
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| Synonym | More Synonyms |
| Description | [Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin[1][2]. |
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| Related Catalog | |
| In Vitro | [Tyr0] Corticotropin Releasing Factor, ovine has a strong binding effect with plasma protein[1]. |
| In Vivo | [Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys[1]. Animal Model: Young adult male cynomolgus monkeys (4.0-6.9 kg)[1] Dosage: 10 mL/h for 198 pg/min or 225 pg/min Administration: Continuous infusions intravenous; collected every 60 min during 5-7 hr Result: Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH). |
| References |
| Molecular Formula | C214H348N60O65S1 |
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| Molecular Weight | 4833.48 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Actions of CRF and its analogs.
Curr. Med. Chem. 6 , 1035-1053, (1999) Corticotropin-releasing factor (CRF), urocortin, sauvagine and urotensin I form the CRF family. These peptides bind with different affinities to two subtypes of CRF receptor (CRFR), CRFR1 and CRFR2. T... |
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Corticotropin-releasing factor (CRF) and endocrine responses to stress: CRF receptors, binding protein, and related peptides.
Proc. Soc. Exp. Biol. Med. 215(1) , 1-10, (1997) Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide, which is recognized as a critical mediator of complimentary, stress-related endocrine, autonomic, and behavioral responses in mamm... |
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Binding of [125I]Tyr-corticotropin-releasing factor to rabbit aorta is reduced by removal of the endothelium.
Eur. J. Pharmacol. 135 , 111-112, (1987)
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| H-Tyr-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2 |