n6-methyl-2'-deoxy-adenosine

Modify Date: 2024-01-14 22:34:26

n6-methyl-2'-deoxy-adenosine structure	Common Name	n6-methyl-2'-deoxy-adenosine
	CAS Number	2002-35-9	Molecular Weight	265.27
	Density	1.72g/cm3	Boiling Point	603.6ºC at 760mmHg
	Molecular Formula	C₁₁H₁₅N₅O₃	Melting Point	N/A
	MSDS	USA	Flash Point	318.8ºC

Use of n6-methyl-2'-deoxy-adenosine

N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	(2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol
Synonym	More Synonyms

Description	N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.72g/cm3
Boiling Point	603.6ºC at 760mmHg
Molecular Formula	C₁₁H₁₅N₅O₃
Molecular Weight	265.27
Flash Point	318.8ºC
Exact Mass	265.11700
PSA	105.32000
Appearance of Characters	Powder \| White to Off-white
Vapour Pressure	2.03E-15mmHg at 25°C
Index of Refraction	1.78
Storage condition	−20°C
Water Solubility	Soluble in water

n6-methyl-2'-deoxy-adenosine MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29349990

2'-DEOXY-1-METH...

CAS#:74873-17-9

~78%

n6-methyl-2'-de...

CAS#:2002-35-9

Literature: Helvetica Chimica Acta, , vol. 69, p. 1034 - 1040

Trimethylsulfon...

CAS#:17287-03-5

2'-Deoxyadenosine

CAS#:958-09-8

~31%

5-(6-dimethylam...

CAS#:35665-58-8

n6-methyl-2'-de...

CAS#:2002-35-9

Detail

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2787 - 2792

trimethylseleno...

CAS#:74230-06-1

2'-Deoxyadenosine

CAS#:958-09-8

~21%

5-(6-dimethylam...

CAS#:35665-58-8

n6-methyl-2'-de...

CAS#:2002-35-9

Detail

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1327 - 1330

2'-deoxyuridine

CAS#:951-78-0

N6-Methyladenine

CAS#:443-72-1

n6-methyl-2'-de...

CAS#:2002-35-9

Literature: Collection of Czechoslovak Chemical Communications, , vol. 59, # 10 p. 2303 - 2330

Precursor 5
CAS#:17287-03-5 Trimethylsulfon... CAS#:958-09-8 2'-Deoxyadenosine CAS#:74230-06-1 trimethylseleno... CAS#:951-78-0 2'-deoxyuridine
CAS#:443-72-1 N6-Methyladenine
DownStream 2
CAS#:443-72-1 N6-Methyladenine CAS#:98056-69-0 5'-DMT-N6-Me-2'-dA

Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.

Br. J. Pharmacol. 171(14) , 3404-19, (2014)

Despite the abundant expression of the UDP-sensitive P2Y6 receptor in urothelial cells and sub-urothelial myofibroblasts its role in the control of bladder function is not well understood.We compared ...

GABA-mediated modulation of ATP-induced intracellular calcium responses in nodose ganglion neurons of the rat.

Neurosci. Lett. 584 , 168-72, (2014)

We examined ATP-induced intracellular Ca(2+) ([Ca(2+)]i) responses in the neurons and satellite cells from one of the viscerosensory ganglia, the nodose ganglion (NG), as well as the GABA-mediated mod...

Pharmacological characterization of the human P2Y13 receptor.

Mol. Pharmacol. 64 , 104-112, (2003)

The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional properties: coupling to Gi and responsivene...

N-6-methyl-2'-deoxyribofuranosil adenine

N6-Methyl-2'-desoxy-adenosin

N6-Methyldeoxyadenosine

2'-Deoxy-N6-methylado

Adenosine,2'-deoxy-N-methyl

N6-Methyl-2'-deoxyadenosine

2'-deoxy-N6-methyladenosine

N6-methyl-2'-deoxy-adenosine