IWP-O1

Modify Date: 2024-01-05 18:09:06

IWP-O1 Structure
IWP-O1 structure
Common Name IWP-O1
CAS Number 2074607-48-8 Molecular Weight 432.48
Density N/A Boiling Point N/A
Molecular Formula C26H20N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IWP-O1


IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].

 Names

Name IWP-O1

 IWP-O1 Biological Activity

Description IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].
Related Catalog
Target

EC50: 80 pM (Porcn)[1].

References

[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.

 Chemical & Physical Properties

Molecular Formula C26H20N6O
Molecular Weight 432.48
Storage condition -20℃
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