Rutin hydrate

Modify Date: 2024-01-02 18:06:24

Rutin hydrate structure	Common Name	Rutin hydrate
	CAS Number	207671-50-9	Molecular Weight	664.56300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃O_16.xH₂O	Melting Point	195°C dec. (Lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Rutin hydrate

Rutin hydrate is a flavonol glycoside, able to cross the blood-brain barrier, and acts by inhibiting JNK and ERK1/2 activation and activating mTOR signalling.

Name	2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-( 6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside trihydrate
Synonym	More Synonyms

Description	Rutin hydrate is a flavonol glycoside, able to cross the blood-brain barrier, and acts by inhibiting JNK and ERK1/2 activation and activating mTOR signalling.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Natural Products >> Flavonoids Research Areas >> Neurological Disease
Target	JNK ERK1 ERK2 mTOR
In Vivo	Rutin hydrate (100 mg/kg) significantly lowers MDA levels and concomitantly increases glutathione (GSH), GSH/oxidized glutathione (GSSG) ratio, total glutathione levels and activities of GPx in the brain of rats. Rutin hydrate alone or in combination with a-tocopherol to CdCl2 intoxicated rats inhibits the declines in the levels of Ach and ChAT activity and significantly inhibited the activities of AChE. Rutin hydrate also inhibits neural apoptosis by inhibiting JNK activation in the brain of control and CdCl2 intoxicated rats and of ERK1/2 activation in the brain of CdCl2 intoxicated rats. In addition, Rutin hydrate activates mTOR/Akt in the brain of control and CdCl2 intoxicated rats[1].
Animal Admin	Rats[1] (1) A control group receives of 0.01 g/mL carboxymethylcellulose (CMC) dissolved in distilled water; (2) α-tocopherol acetate treated group: control rats receive α-tocopherol (120 IU/rat) diluted in 0.1 mL of coconut oil; (3) Rutin hydrate treated control group (control + Rutin hydrate): control rats receive Rutin hydrate (100 mg/kg); (4) CdCl2 intoxicated group receives CdCl2 at a final dose of 5 mg/kg to induce neurotoxicity; (5) CdCl2 + Rutin hydrate treated group (CdCl2 + Rutin hydrate) receives CdCl2 (5 mg/kg) and receives a coincided dose of Rutin hydrate (100 mg/kg body weight); (6) CdCl2 + Rutin hydrate + α-tocopherol acetate-treated group receives CdCl2 (5 mg/kg) and receives concomitant dose of Rutin hydrate (100 mg/kg) in conjugation with α-tocopherol acetate (120 IU/rat) that is diluted in 0.1 mL of coconut oil. All treatments are given by orogastric gavage with a polyethylene catheter PE 190 daily for 30 days[1].
References	[1]. Abdel-Aleem GA, et al. Rutin hydrate ameliorates cadmium chloride-induced spatial memory loss and neural apoptosis in rats by enhancing levels of acetylcholine, inhibiting JNK and ERK1/2 activation and activating mTOR signalling. Arch Physiol Biochem. 2018 Oct;124(4):367-377.

Melting Point	195°C dec. (Lit.)
Molecular Formula	C₂₇H₃O_16.xH₂O
Molecular Weight	664.56300
Exact Mass	664.18500
PSA	297.12000

Rutin hydrate MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
RIDADR	NONH for all modes of transport

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Rutin hydrate

MFCD00149490

EINECS 205-814-1