E3 ligase Ligand-Linker Conjugates 30

Modify Date: 2024-01-16 23:00:09

E3 ligase Ligand-Linker Conjugates 30 Structure
E3 ligase Ligand-Linker Conjugates 30 structure
 Common Name E3 ligase Ligand-Linker Conjugates 30
CAS Number 2093416-31-8 Molecular Weight 448.47
Density N/A Boiling Point N/A
Molecular Formula C21H28N4O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of E3 ligase Ligand-Linker Conjugates 30


E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrader[1].

 Names

Name E3 ligase Ligand-Linker Conjugates 30

 E3 ligase Ligand-Linker Conjugates 30 Biological Activity

Description E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrader[1].
Related Catalog
Target

Cereblon

References

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.

 Chemical & Physical Properties

Molecular Formula C21H28N4O7
Molecular Weight 448.47
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