Topoisomerase I inhibitor 8
Modify Date: 2024-01-12 19:52:23
Topoisomerase I inhibitor 8 structure
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Common Name | Topoisomerase I inhibitor 8 | ||
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| CAS Number | 210346-40-0 | Molecular Weight | 420.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H21FN2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Topoisomerase I inhibitor 8Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1]. |
| Name | Topoisomerase I inhibitor 8 |
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| Description | Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1]. |
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| Related Catalog | |
| Target |
Topoisomerase I |
| In Vitro | Topoisomerase I inhibitor 8 (compound 57) shows antitumor activities against three cell line cultures with IC50s of 0.22 ng/mL (P388), 2.06 ng/mL (HOC-21), 0.17 ng/mL (QG-56), respectively[1]. Topoisomerase I inhibitor 8 results the change in DNA from the supercoiled form to the relaxed form in the presence of topoisomerase I, shows stronger effective than SN-38 (HY-13704), with IC50 of compound/IC50 of SN-38=0.51[1]. |
| References |
| Molecular Formula | C24H21FN2O4 |
|---|---|
| Molecular Weight | 420.43 |