Boc-Gly-PEG3-endo-BCN

Modify Date: 2024-01-09 14:34:18

Boc-Gly-PEG3-endo-BCN Structure
Boc-Gly-PEG3-endo-BCN structure
Common Name Boc-Gly-PEG3-endo-BCN
CAS Number 2110444-63-6 Molecular Weight 553.69
Density N/A Boiling Point N/A
Molecular Formula C28H47N3O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-Gly-PEG3-endo-BCN


Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

 Names

Name Boc-gly-PEG3-endo-BCN

 Boc-Gly-PEG3-endo-BCN Biological Activity

Description Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog
Target

PEGs

Alkyl/ether

Cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Molecular Formula C28H47N3O8
Molecular Weight 553.69

 Safety Information

Hazard Codes Xi
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