Gardenin A
Modify Date: 2024-01-04 10:57:32
Gardenin A structure
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Common Name | Gardenin A | ||
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| CAS Number | 21187-73-5 | Molecular Weight | 418.39400 | |
| Density | 1.3g/cm3 | Boiling Point | 624.2ºC at 760 mmHg | |
| Molecular Formula | C21H22O9 | Melting Point | 162-163ºC | |
| MSDS | N/A | Flash Point | 218.5ºC | |
Use of Gardenin AGardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects[1][2]. |
| Name | 5-hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one |
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| Synonym | More Synonyms |
| Description | Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects[1][2]. |
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| Related Catalog | |
| In Vitro | Gardenin A (10-20 μM; 48 h) 可诱导 PC12 细胞神经突生长，(10 μM; 24 小时和 48 小时) 还增加神经元分化和突触形成标记蛋白、生长相关蛋白-43 (GAP-43) 和突触素的表达[1]。 Gardenin A (10 μM; 30-120分钟) 显著诱导环 AMP 反应元件结合蛋白(CREB) 的磷酸化和 CRE 介导的转录，这是通过抑制剂 2-萘酚AS-E 磷酸盐 (KG-501) 或使用 CREB siRNA 来抑制的[1]。 Gardenin A (10 μM; 15-120分钟) 增加 ERK 磷酸化水平，提高 PKA 和 PKC 活性[1]。 Cell Viability Assay[1] Cell Line: PC12 cells Concentration: 2, 5, 10, 20 μM Incubation Time: 48 hours Result: showed cell growth supporting effect at higher concentrations (10-20 µM) and did not exert detectable 237 cytotoxicity on PC12 cells after 48 h incubation in low serum medium. Western Blot Analysis[1] Cell Line: PC12 cells Concentration: 10 μM Incubation Time: 0, 15, 30, 60, and 120 min Result: Significantly increased the phosphorylation of ERK1/2 (Thr202/Tyr204) at 15 min, subsequently reduced after 30 min. Increased PKC and PKA activity peaked at 15 min.Increased CREB phosphorylation. |
| In Vivo | Gardenin A (0.1-25 mg/kg; 口服; 单剂量) 具有神经药理作用，包括镇静、抗焦虑、抗抑郁和抗惊厥作用的小鼠[2]。 栀子苷A (1-10 mg/kg; 口服; 单次剂量) 不影响小鼠的运动协调和延迟惊厥的发生[2]。 Animal Model: Male Balb/c mice (24-32 g)[2] Dosage: 1 mg/kg, 10 mg/kg, 25 mg/kg Administration: Oral gavage; single dose Result: Showed sedative effects at a dose of 25 mg/kg, which increased the duration of sleep but did not alter sleep onset. |
| References |
| Density | 1.3g/cm3 |
|---|---|
| Boiling Point | 624.2ºC at 760 mmHg |
| Melting Point | 162-163ºC |
| Molecular Formula | C21H22O9 |
| Molecular Weight | 418.39400 |
| Flash Point | 218.5ºC |
| Exact Mass | 418.12600 |
| PSA | 105.82000 |
| LogP | 3.21720 |
| Vapour Pressure | 3.57E-16mmHg at 25°C |
| Index of Refraction | 1.573 |
| Storage condition | -20°C |
| Hazard Codes | T+ |
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| HS Code | 2914509090 |
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Gardenin A CAS#:21187-73-5 |
| Literature: Banerji, J.; Das, B.; Chakrabarty, R.; Jha, H. C. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 597 - 599 |
| Precursor 1 | |
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| DownStream 1 | |
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
| Gardenin A |
| 5OH3'4'5'6,7,8-hexMeO-Flavone |
| 3',4',5',6,7,8-Hexamethoxy-5-hydroxyflavone |
| Gardenin |
| 5-hydroxy-6,7,8,3',4',5'-hexamethoxyflavone |
| Flavone,5-hydroxy-3',4',5',6,7,8-hexamethoxy |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Gardenin A
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Gardenin A
- Price: ￥4068.0/10mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 4H-1-Benzopyran-4-one,5-hydroxy-6,7,8- trimethoxy-2-(3,4,5-trimethoxyphenyl)-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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