HIV-1 inhibitor-30

Modify Date: 2023-01-16 17:47:51

HIV-1 inhibitor-30 structure	Common Name	HIV-1 inhibitor-30
	CAS Number	2132412-77-0	Molecular Weight	357.83
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₀ClN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIV-1 inhibitor-30

HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS[1].

Name	HIV-1 inhibitor-30

Description	HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	EC50: 40 nM (HIV-1 WT)[1] IC50: 80 nM (HIV-1 RT DNA polymerase)[1]
References	[1]. Xu C,et al. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. Eur J Med Chem. 2020 Mar 1;189:112071.

Molecular Formula	C₁₉H₂₀ClN₃O₂
Molecular Weight	357.83

HIV-1 inhibitor-30

Use of HIV-1 inhibitor-30

Names

HIV-1 inhibitor-30 Biological Activity

Chemical & Physical Properties