Pomalidomide 4'-PEG5-acid

Modify Date: 2024-01-18 16:49:55

Pomalidomide 4'-PEG5-acid Structure
Pomalidomide 4'-PEG5-acid structure
Common Name Pomalidomide 4'-PEG5-acid
CAS Number 2139348-63-1 Molecular Weight 565.57
Density N/A Boiling Point N/A
Molecular Formula C26H35N3O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pomalidomide 4'-PEG5-acid


Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology[1].

 Names

Name Pomalidomide 4'-PEG5-acid

 Pomalidomide 4'-PEG5-acid Biological Activity

Description Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. [1]Jing Liu, et al. Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use. WO2020173440A1.

 Chemical & Physical Properties

Molecular Formula C26H35N3O11
Molecular Weight 565.57
Storage condition -20°C
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