Fmoc-amino-PEG5-acid

Modify Date: 2024-01-07 11:19:24

Fmoc-amino-PEG5-acid Structure
Fmoc-amino-PEG5-acid structure
Common Name Fmoc-amino-PEG5-acid
CAS Number 882847-32-7 Molecular Weight 531.59500
Density 1.210±0.06 g/cm3 (20ºC 760 Torr) Boiling Point 711.4±60.0°C at 760 mmHg
Molecular Formula C28H37NO9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fmoc-amino-PEG5-acid


Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid
Synonym More Synonyms

 Fmoc-amino-PEG5-acid Biological Activity

Description Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.210±0.06 g/cm3 (20ºC 760 Torr)
Boiling Point 711.4±60.0°C at 760 mmHg
Molecular Formula C28H37NO9
Molecular Weight 531.59500
Exact Mass 531.24700
PSA 121.78000
LogP 3.47370

 Safety Information

HS Code 29225090

 Synonyms

fmoc-18-amino-4,7,10,13,16-pentaoxaoctadecanoic acid
5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
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