2093152-86-2

2093152-86-2 structure

Name: N-(Amino-PEG5)-N-bis(PEG4-acid)
Chemical Name: N-(Amino-PEG5)-N-bis(PEG4-acid)
CAS Number: 2093152-86-2
Molecular Formula: C₃₄H₆₈N₂O₁₇
Molecular Weight: 776.91
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-04-08 09:38:27
Modify Date: 2024-01-31 07:33:04
N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids[1].

Name	N-(Amino-PEG5)-N-bis(PEG4-acid)

Description	N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Pignatello, R., et al. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG5000 polymers. Materials Science and Engineering: C, 2015.46, 470–481.