Fmoc-amino-PEG3-CH2COOH

Modify Date: 2024-01-10 22:24:01

Fmoc-amino-PEG3-CH2COOH Structure
Fmoc-amino-PEG3-CH2COOH structure
Common Name Fmoc-amino-PEG3-CH2COOH
CAS Number 139338-72-0 Molecular Weight 429.463
Density 1.3±0.1 g/cm3 Boiling Point 651.1±65.0 °C at 760 mmHg
Molecular Formula C23H27NO7 Melting Point 46℃
MSDS N/A Flash Point 347.6±34.3 °C

 Use of Fmoc-amino-PEG3-CH2COOH


Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (3E)-1-(9H-Fluoren-9-yl)-3-hydroxy-2,7,10,13-tetraoxa-4-azapentad ec-3-en-15-oic acid
Synonym More Synonyms

 Fmoc-amino-PEG3-CH2COOH Biological Activity

Description Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 651.1±65.0 °C at 760 mmHg
Melting Point 46℃
Molecular Formula C23H27NO7
Molecular Weight 429.463
Flash Point 347.6±34.3 °C
Exact Mass 429.178741
PSA 106.81000
LogP 2.75
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.574
Storage condition 2-8°C

 Synthetic Route

~63%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

~71%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Gomez, Francisco L. Guerra; Uehara, Tomoya; Rokugawa, Takemi; Higaki, Yusuke; Suzuki, Hiroyuki; Hanaoka, Hirofumi; Akizawa, Hiromichi; Arano, Yasushi Bioconjugate Chemistry, 2012 , vol. 23, # 11 p. 2229 - 2238

~51%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Boumrah, Derradji; Campbell, Malcolm M.; Fenner, Simon; Kinsman, Richard G. Tetrahedron, 1997 , vol. 53, # 20 p. 6977 - 6992

~%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Inorganica Chimica Acta, , vol. 365, # 1 p. 38 - 48

~%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Inorganica Chimica Acta, , vol. 365, # 1 p. 38 - 48

~%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Inorganica Chimica Acta, , vol. 365, # 1 p. 38 - 48

~%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Inorganica Chimica Acta, , vol. 365, # 1 p. 38 - 48

~%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Inorganica Chimica Acta, , vol. 365, # 1 p. 38 - 48

~%

Fmoc-amino-PEG3-CH2COOH Structure

Fmoc-amino-PEG3...

CAS#:139338-72-0

Literature: Inorganica Chimica Acta, , vol. 365, # 1 p. 38 - 48

 Synonyms

FMOC-PHE(3-OH)-OH
FMOC-L-M-TYR
FMOC-3-HYDROXYL-L-PHENYLALANINE
2-{2-[2-(9-fluorenylmethyloxycarbonylaminoethoxy)ethoxy]ethoxy}acetic acid
Fmoc-D-phe(3-OH)-OH
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
Fmoc-3-hydroxy-L-Phe
11-(fluoren-9-ylmethyloxycarbonyl)amino-3,6,9-trioxaundecanoic acid
(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy}ethoxy)acetic acid
N-FMOC-3-HYDROXY-L-PHENYLALANINE
Fmoc-meta-tyrosine
2,7,10,13-Tetraoxa-4-azapentadecan-15-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-
Fmoc-11-amino-3,6,9-trioxaundecanoic acid
Fmoc-Teg-OH
Fmoc-PEG3-acetic acid
5,8,11-Trioxa-2-azatridecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
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