Tos-PEG3

Modify Date: 2024-01-01 18:11:30

Tos-PEG3 Structure
Tos-PEG3 structure
Common Name Tos-PEG3
CAS Number 77544-68-4 Molecular Weight 304.35900
Density 1.234±0.06 g/cm3 Boiling Point 460.0±35.0 °C
Molecular Formula C13H20O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tos-PEG3


Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].

 Names

Name 2-[2-(2-Hydroxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate
Synonym More Synonyms

 Tos-PEG3 Biological Activity

Description Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Noël M, et al. Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation.J Org Chem. 2019 Nov 15;84(22):14854-14860.

 Chemical & Physical Properties

Density 1.234±0.06 g/cm3
Boiling Point 460.0±35.0 °C
Molecular Formula C13H20O6S
Molecular Weight 304.35900
Exact Mass 304.09800
PSA 90.44000
LogP 1.80660

 Safety Information

HS Code 2909499000

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

Ethanol,2-[2-(2-hydroxyethoxy)ethoxy]-,1-(4-methylbenzenesulfonate)
2-(2-(2-Hydroxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
triethyleneglycol monotosylate
2,2'-[ethane-1,2-diylbis(oxy)]bis[ethanol] mono(4-methylbenzenesulfonate)
p-toluenesulfonic acid 2-(2-(2-hydroxyethoxy)ethoxy)ethoxy ester
Tos-PEG4
HO(C2H4O)3Tos
toluene-4-sulfonic acid 2-[2-(2-hydroxy-ethoxy)ethoxy]ethyl ester
Ts(OCH2CH2)3OH
Tos-PEG3
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