2'-O-Methyladenosine
2'-O-Methyladenosine structure
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Common Name | 2'-O-Methyladenosine | ||
|---|---|---|---|---|
| CAS Number | 2140-79-6 | Molecular Weight | 281.268 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 623.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C11H15N5O4 | Melting Point | 200-202ºC | |
| MSDS | USA | Flash Point | 331.0±34.3 °C | |
Use of 2'-O-Methyladenosine2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities [1][2]. |
| Name | cordysinin B |
|---|---|
| Synonym | More Synonyms |
| Description | 2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities [1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | 2'-O-Methyladenosine (100, 200 mg/kg, ip, single dose) exhibits unique hypotensive activities in rats[2]. Animal Model: Male spontaneously hypertensive rats (SHR; 16 weeks old)[2]. Dosage: 100, 200 mg/kg. Administration: IP, single dose. Result: Exhibited a significant hypotensive effect in decreasing blood pressure by about 40-50%. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 623.8±65.0 °C at 760 mmHg |
| Melting Point | 200-202ºC |
| Molecular Formula | C11H15N5O4 |
| Molecular Weight | 281.268 |
| Flash Point | 331.0±34.3 °C |
| Exact Mass | 281.112396 |
| PSA | 128.54000 |
| LogP | -0.15 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.795 |
| Storage condition | −20°C |
| Precursor 9 | |
|---|---|
| DownStream 5 | |
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CAS#:30891-53-3| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency.
Pediatr. Res. 16(5) , 362-9, (1982) We have identified seven adenine nucleosides in urines of untreated adenosine deaminase (ADA) deficient patients, four of which (adenosine, 2'-deoxyadenosine, 1-methyladenosine and N6-methyladenosine)... |
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Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.
Chem. Biol. 1(1) , 39-45, (1994) The stability of hybrids of 2'-O-methyl-ribonucleotides with complementary RNA is considerably higher than that of the corresponding DNA.RNA duplexes. The 2'-O-modified ribonucleotides are thus an att... |
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Effect of PGE2 and of agents that raise cAMP levels on macrophage activation induced by IFN-gamma and TNF-alpha.
J. Leukoc. Biol. 58(2) , 217-24, (1995) The effect of prostaglandin (PG) E2 on macrophage activation by interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) was evaluated. Murine macrophages infected with Leishmania enri... |
| UNII-02YX82IHZ5 |
| 2'-O-Methyl adenosine |
| 2'-methyl-adenosine |
| 2'-O-methylAdo |
| 2′-O-Methyladenosine |
| (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol |
| 2'-methoxyadenosine |
| 2'-OMeAdenosine |
| MFCD00056002 |
| Adenosine, 2'-O-methyl- |
| 2'-O-Methyladenosine |
| 2'-O-Methyl-D-adenosine |
| (2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol |
| Adenosine,2'-O-methyl |
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