CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AU7175000
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CHEMICAL NAME :
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Adenosine
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CAS REGISTRY NUMBER :
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58-61-7
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LAST UPDATED :
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199701
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DATA ITEMS CITED :
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16
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MOLECULAR FORMULA :
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C10-H13-N5-O4
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MOLECULAR WEIGHT :
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267.28
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WISWESSER LINE NOTATION :
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T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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240 ug/kg
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TOXIC EFFECTS :
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Cardiac - arrhythmias (including changes in conduction)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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143 ug/kg/I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - headache
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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50 ug/kg/1M-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - bronchiolar constriction
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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360 ug/kg/1H-I
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Cardiac - change in rate
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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257 ug/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - cyanosis
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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171 ug/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - coma Cardiac - pulse rate
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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257 ug/kg/1D-I
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TOXIC EFFECTS :
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Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>20 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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Cytogenetic analysis
MUTATION DATA
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TYPE OF TEST :
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DNA damage
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TEST SYSTEM :
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Mammal - species unspecified Lymphocyte
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DOSE/DURATION :
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60 mmol/L
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REFERENCE :
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PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3937 No. of Facilities: 77 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 556 (estimated) No. of Female Employees: 387 (estimated)
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