8-Bromoadenosine

Modify Date: 2024-01-02 19:26:34

8-Bromoadenosine Structure
8-Bromoadenosine structure
Common Name 8-Bromoadenosine
CAS Number 2946-39-6 Molecular Weight 346.14
Density 2.5±0.1 g/cm3 Boiling Point 717.7±70.0 °C at 760 mmHg
Molecular Formula C10H12BrN5O4 Melting Point 210-212 °C (dec.)(lit.)
MSDS USA Flash Point 387.8±35.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 8-Bromoadenosine


8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

 Names

Name 8-bromoadenosine
Synonym More Synonyms

 8-Bromoadenosine Biological Activity

Description 8-Bromoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
Related Catalog
References

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.  

 Chemical & Physical Properties

Density 2.5±0.1 g/cm3
Boiling Point 717.7±70.0 °C at 760 mmHg
Melting Point 210-212 °C (dec.)(lit.)
Molecular Formula C10H12BrN5O4
Molecular Weight 346.14
Flash Point 387.8±35.7 °C
Exact Mass 345.007263
PSA 139.54000
LogP -0.30
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.941
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25-S22
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

~82%

8-Bromoadenosine Structure

8-Bromoadenosine

CAS#:2946-39-6

Literature: European Journal of Organic Chemistry, , # 10 p. 1515 - 1521

~46%

8-Bromoadenosine Structure

8-Bromoadenosine

CAS#:2946-39-6

Literature: US2013/72506 A1, ; Paragraph 0128 ;

~%

8-Bromoadenosine Structure

8-Bromoadenosine

CAS#:2946-39-6

Literature: US2003/8841 A1, ;

~%

8-Bromoadenosine Structure

8-Bromoadenosine

CAS#:2946-39-6

Literature: US2003/8841 A1, ;

~%

8-Bromoadenosine Structure

8-Bromoadenosine

CAS#:2946-39-6

Literature: US2003/8841 A1, ;

~%

8-Bromoadenosine Structure

8-Bromoadenosine

CAS#:2946-39-6

Literature: US2003/8841 A1, ;

~%

8-Bromoadenosine Structure

8-Bromoadenosine

CAS#:2946-39-6

Literature: US2003/8841 A1, ;

 Articles40

More Articles
PKA signaling drives mammary tumorigenesis through Src.

Oncogene 34(9) , 1160-73, (2015)

Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary ep...

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...

Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.

J. Immunol. 194 , 5472-87, (2015)

PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucin...

 Synonyms

8-Br-A
8-Bromoadenine-9-β-D-ribofuranoside
8-Bromoadenosine
(2R,3R,4S,5R)-2-(6-Amino-8-bromo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Adenosine, 8-bromo-
8-BROMO-D-ADENOSINE
6-AMINO-8-BROMOPURINE RIBOSIDE
8-bromo-adenosine
MFCD00005733
EINECS 220-959-0
Top Suppliers:I want be here



Get all suppliers and price by the below link:

8-Bromoadenosine suppliers


Price: ¥137.2/250mg

Reference only. check more 8-Bromoadenosine price