Apelin 17

Modify Date: 2024-01-10 18:56:53

Apelin 17 Structure
Apelin 17 structure
Common Name Apelin 17
CAS Number 217082-57-0 Molecular Weight 2138.55000
Density N/A Boiling Point N/A
Molecular Formula C96H156N34O20S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Apelin 17


Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

 Names

Name Apelin-17 (human, bovine)
Synonym More Synonyms

 Apelin 17 Biological Activity

Description Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].
Related Catalog
Target

HIV-1

HIV-2

References

[1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476.

[2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172.

[3]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

 Chemical & Physical Properties

Molecular Formula C96H156N34O20S
Molecular Weight 2138.55000
Exact Mass 2137.20000
PSA 919.49000
LogP 4.58470

 Synonyms

h-lys-phe-arg-arg-gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-phe-oh trifluoroacetate
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