Aminopurvalanol A
Modify Date: 2024-01-04 12:12:35
Aminopurvalanol A structure
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Common Name | Aminopurvalanol A | ||
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| CAS Number | 220792-57-4 | Molecular Weight | 403.90900 | |
| Density | 1.4g/cm3 | Boiling Point | 639ºC at 760mmHg | |
| Molecular Formula | C19H26ClN7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 340.2ºC | |
Use of Aminopurvalanol AAminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2]. |
| Name | Aminopurvalanol A,(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
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| Synonym | More Synonyms |
| Description | Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2]. |
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| Related Catalog | |
| Target |
Cyclins/Cdk[1] |
| In Vitro | Aminopurvalanol A (5 and 40 μM; 8 hours) inhibits cell growth primarily by arresting the cells in the G2 phase of the cell cycle and, at higher concentration, triggering apoptosis[2]. Cell Cycle Analysis[2] Cell Line: Human U937 leukemic cells Concentration: 5 and 40 μM Incubation Time: 8 hours Result: Increased the number of cells with a 4N DNA content as early as 8 h after the beginning of treatment at 5 μM. 40 μM led to cellular fragmentation and cells with an irregular DNA distribution, characteristic of apoptotic cell populations. Apoptosis Analysis[2] Cell Line: Human U937 leukemic cells Concentration: 5 and 40 μM Incubation Time: 8 hours Result: 40 μM Aminopurvalanol A led to apoptosis rather than after the beginning of treatment at 5 μM. |
| References |
| Density | 1.4g/cm3 |
|---|---|
| Boiling Point | 639ºC at 760mmHg |
| Molecular Formula | C19H26ClN7O |
| Molecular Weight | 403.90900 |
| Flash Point | 340.2ºC |
| Exact Mass | 403.18900 |
| PSA | 113.91000 |
| LogP | 4.54240 |
| Vapour Pressure | 3.34E-17mmHg at 25°C |
| Index of Refraction | 1.678 |
| ng-97 |
| aminopurvalanol a |