MSC 1094308

Modify Date: 2024-01-11 21:45:44

MSC 1094308 Structure
MSC 1094308 structure
Common Name MSC 1094308
CAS Number 2219320-08-6 Molecular Weight 462.55
Density N/A Boiling Point N/A
Molecular Formula C29H29F3N2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MSC 1094308


MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].

 Names

Name MSC1094308
Synonym More Synonyms

 MSC 1094308 Biological Activity

Description MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1].
Related Catalog
Target

IC50: 0.71 μM (VPS4B), 7.2 μM (p97)[1].

References

[1]. Pöhler R, et al. A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1576-1580.

 Chemical & Physical Properties

Molecular Formula C29H29F3N2
Molecular Weight 462.55
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi

 Synonyms

MFCD31814427
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