CRT 0066854 hydrochloride
Modify Date: 2024-01-15 16:44:26
CRT 0066854 hydrochloride structure
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Common Name | CRT 0066854 hydrochloride | ||
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| CAS Number | 2250019-91-9 | Molecular Weight | 452.01 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H26ClN5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CRT 0066854 hydrochlorideCRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1]. |
| Name | CRT0066854 hydrochloride |
|---|
| Description | CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1]. |
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| Related Catalog | |
| Target |
PKCζ:639 nM (IC50) ROCKII:620 nM (IC50) |
| In Vitro | CRT0066854 hydrochloride displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates[1]. CRT0066854 hydrochloride (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM[1]. |
| References |
| Molecular Formula | C24H26ClN5S |
|---|---|
| Molecular Weight | 452.01 |