Top1 inhibitor 1

Modify Date: 2024-01-02 17:05:38

Top1 inhibitor 1 structure	Common Name	Top1 inhibitor 1
	CAS Number	2302772-05-8	Molecular Weight	426.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₂N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Top1 inhibitor 1

Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].

Name	Top1 inhibitor 1

Description	Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	IC50: 29 nM (human topoisomerase I)[1]
In Vitro	Top1 inhibitor 1 reveals cytotoxicity in cancerous cells including MCF7 (IC50: 2.74 µM), HeLa (IC50: 2.61 µM), HCT116 (IC50: 2.34 µM), NIH: OVCAR-3 (IC50: 2.35 µM) cells compared to the non-cancerous cells like HEK293 (IC50: 8.34 µM) [1].
References	[1]. Kundu B, et al. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. J Med Chem. 2019 Apr 11; 62(7):3428-3446.

Molecular Formula	C₂₄H₂₂N₆O₂
Molecular Weight	426.47

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Top1 inhibitor 1
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Purity: 98.0%
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