CTP Synthetase-IN-1
Modify Date: 2024-04-05 19:26:50
CTP Synthetase-IN-1 structure
|
Common Name | CTP Synthetase-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2338811-71-3 | Molecular Weight | 512.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H19F3N6O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CTP Synthetase-IN-1CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects[1]. |
| Name | CTP Synthetase-IN-1 |
|---|
| Description | CTP Synthetase-IN-1 is a potent, orally active cytidine 5'-triphosphate synthetase (CTPS) inhibitor with IC50s of 32 nM and 18 nM for human CTPS1 and human CTPS2, respectively. CTP Synthetase-IN-1 has anti-inflammatory effects[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 32 nM (human CTPS1) and 18 nM (human CTPS2)[1] |
| In Vitro | CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively[1]. |
| In Vivo | CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model[1]. Animal Model: Mouse collagen-induced arthritis (CIA) model[1] Dosage: 10 mg/kg and 50 mg/kg Administration: p.o; twice daily; for 18 days Result: Resulted in improvements in specific indicators of disease severity. |
| References |
| Molecular Formula | C20H19F3N6O3S2 |
|---|---|
| Molecular Weight | 512.53 |