(S,R,S)-AHPC-C2-NH2 dihydrochloride

Modify Date: 2024-04-02 19:59:08

(S,R,S)-AHPC-C2-NH2 dihydrochloride Structure
(S,R,S)-AHPC-C2-NH2 dihydrochloride structure
Common Name (S,R,S)-AHPC-C2-NH2 dihydrochloride
CAS Number 2341796-73-2 Molecular Weight 574.56
Density N/A Boiling Point N/A
Molecular Formula C25H37Cl2N5O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (S,R,S)-AHPC-C2-NH2 dihydrochloride


(S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs[1].

 Names

Name (S,R,S)-AHPC-C2-NH2 dihydrochloride

 (S,R,S)-AHPC-C2-NH2 dihydrochloride Biological Activity

Description (S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs[1].
Related Catalog
Target

VHL

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. WO2020038415A1.

 Chemical & Physical Properties

Molecular Formula C25H37Cl2N5O4S
Molecular Weight 574.56

 Safety Information

Hazard Codes Xi
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