BSJ-04-132
Modify Date: 2024-01-14 20:20:09
BSJ-04-132 structure
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Common Name | BSJ-04-132 | ||
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| CAS Number | 2349356-39-2 | Molecular Weight | 819.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C42H49N11O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BSJ-04-132BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1]. |
| Name | BSJ-04-132 |
|---|
| Description | BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity[1]. |
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| Related Catalog | |
| Target |
CDK4/D1:50.6 nM (IC50) CDK6/D1:30 nM (IC50) |
| In Vitro | BSJ-04-132 (0.1-5 μM; for 4 hours) only resultes in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3[1]. Western Blot Analysis[1] Cell Line: Wildtype (WT) or Crbn-/- Jurkat cells Concentration: 0.1, 0.5, 1, 5 μM Incubation Time: For 4 hours Result: Only resulted in degradation of CDK4 in WT cells, not CDK6 and IKZF1/3. |
| References |
| Molecular Formula | C42H49N11O7 |
|---|---|
| Molecular Weight | 819.91 |
| Hazard Codes | Xi |
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