15-LOX-1 inhibitor 1

Modify Date: 2024-01-09 19:26:17

15-LOX-1 inhibitor 1 Structure
15-LOX-1 inhibitor 1 structure
Common Name 15-LOX-1 inhibitor 1
CAS Number 2349374-37-2 Molecular Weight 412.866
Density 1.3±0.1 g/cm3 Boiling Point 683.5±55.0 °C at 760 mmHg
Molecular Formula C22H21ClN2O4 Melting Point N/A
MSDS N/A Flash Point 367.2±31.5 °C

 Use of 15-LOX-1 inhibitor 1


15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1].

 Names

Name 9c(i472)
Synonym More Synonyms

 15-LOX-1 inhibitor 1 Biological Activity

Description 15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1].
Related Catalog
Target

15-LOX-1:0.19 μM (IC50)

In Vitro 15-LOX-1 inhibitor 1 (Compound 9c) (0-5 μM; 24 hours) protects RAW 264.7 macrophages from LPS-induced cell death and shows stronger, dose-dependent effects with a 20% viability increase at 5 μM[1]. Cell Viability Assay[1] Cell Line: RAW 264.7 macrophages Concentration: 0, 0.2, 1, 5 μM 15-LOX-1 inhibitor 1 and lipopolysaccharides (LPS) (100 μg/mL) Incubation Time: 24 hours Result: Showed stronger, dose-dependent effects with a 20% viability increase at 5 μM.
References

[1]. Guo H, et al. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. J Med Chem. 2019;62(9):4624-4637.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 683.5±55.0 °C at 760 mmHg
Molecular Formula C22H21ClN2O4
Molecular Weight 412.866
Flash Point 367.2±31.5 °C
Exact Mass 412.118988
LogP 4.74
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.648

 Synonyms

Ethyl 6-chloro-3-{(1E)-3-[(2-methoxybenzyl)amino]-3-oxo-1-propen-1-yl}-1H-indole-2-carboxylate
9c(i472)
1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester
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