K-Ras G12C-IN-4

Modify Date: 2024-01-15 11:55:37

K-Ras G12C-IN-4 structure	Common Name	K-Ras G12C-IN-4
	CAS Number	2376328-55-9	Molecular Weight	561.07
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₃ClN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of K-Ras G12C-IN-4

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].

Name	K-Ras G12C-IN-4

Description	K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Ras
In Vitro	K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1]. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].
References	[1]. Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308.

Molecular Formula	C₃₁H₃₃ClN₄O₄
Molecular Weight	561.07

DC Chemicals Limited
China
Product Name: K-Ras G12C-IN-4
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

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