K-Ras-IN-1

Modify Date: 2024-01-08 18:35:22

K-Ras-IN-1 Structure
K-Ras-IN-1 structure
Common Name K-Ras-IN-1
CAS Number 84783-01-7 Molecular Weight 207.292
Density 1.3±0.1 g/cm3 Boiling Point 332.1±44.0 °C at 760 mmHg
Molecular Formula C11H13NOS Melting Point N/A
MSDS N/A Flash Point 154.7±28.4 °C

 Use of K-Ras-IN-1


K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)

 Names

Name 1-[(2-Hydroxyphenyl)thioxomethyl]pyrrolidine
Synonym More Synonyms

 K-Ras-IN-1 Biological Activity

Description K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)
Related Catalog
References

[1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538.

[2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-6143

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 332.1±44.0 °C at 760 mmHg
Molecular Formula C11H13NOS
Molecular Weight 207.292
Flash Point 154.7±28.4 °C
Exact Mass 207.071777
LogP 2.06
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.668
Storage condition 2-8℃

 Synonyms

(2-Hydroxyphenyl)(1-pyrrolidinyl)methanethione
1-[(2-Hydroxyphenyl)thioxomethyl]pyrrolidine
(2-Hydroxyphenyl)(1-pyrrolidinyl)methanthion
(2-Hydroxyphényl)(1-pyrrolidinyl)méthanethione
Methanethione, (2-hydroxyphenyl)-1-pyrrolidinyl-
K-Ras-IN-1
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Price: $462/10mM*1mLinDMSO

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