Thalidomide-O-amido-C6-NH2 hydrochloride

Modify Date: 2024-07-23 20:29:34

Thalidomide-O-amido-C6-NH2 hydrochloride Structure
Thalidomide-O-amido-C6-NH2 hydrochloride structure
Common Name Thalidomide-O-amido-C6-NH2 hydrochloride
CAS Number 2376990-31-5 Molecular Weight 466.92
Density N/A Boiling Point N/A
Molecular Formula C21H27ClN4O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-O-amido-C6-NH2 hydrochloride


Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

 Names

Name Thalidomide-O-amido-C6-NH2 hydrochloride

 Thalidomide-O-amido-C6-NH2 hydrochloride Biological Activity

Description Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1

 Chemical & Physical Properties

Molecular Formula C21H27ClN4O6
Molecular Weight 466.92

 Safety Information

Hazard Codes Xi