1950635-13-8

1950635-13-8 structure

Name: Thalidomide-O-amido-C6-NH2
Chemical Name: Thalidomide-O-amido-C6-NH2
CAS Number: 1950635-13-8
Molecular Formula: C₂₁H₂₆N₄O₆
Molecular Weight: 430.45
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2021-09-11 22:35:08
Modify Date: 2024-01-10 08:34:40
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Name	Thalidomide-O-amido-C6-NH2

Description	Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1.

Molecular Formula	C₂₁H₂₆N₄O₆
Molecular Weight	430.45

Hazard Codes	Xi