2360527-40-6
2360527-40-6 structure
- Name: Thalidomide-O-amido-C5-NH2
- Chemical Name: N-(5-Aminopentyl)-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
- CAS Number: 2360527-40-6
- Molecular Formula: C20H24N4O6
- Molecular Weight: 416.428
- Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
- Create Date: 2021-06-12 13:34:18
- Modify Date: 2024-01-19 21:01:28
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Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
| Name | N-(5-Aminopentyl)-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide |
|---|---|
| Synonyms |
Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
N-(5-Aminopentyl)-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide |
| Description | Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. |
|---|---|
| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 757.3±60.0 °C at 760 mmHg |
| Molecular Formula | C20H24N4O6 |
| Molecular Weight | 416.428 |
| Flash Point | 411.8±32.9 °C |
| Exact Mass | 416.169586 |
| LogP | -0.48 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.599 |
| Hazard Codes | Xi |
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