Anticancer agent 48

Modify Date: 2024-01-05 12:56:22

Anticancer agent 48 structure	Common Name	Anticancer agent 48
	CAS Number	2395009-13-7	Molecular Weight	443.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₅N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Anticancer agent 48

Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1].

Name	Anticancer agent 48

Description	Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 µM and 14 nM, respectively[1]. Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively[1]. Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively[1].
In Vivo	Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects[1]. Animal Model: 8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)[1] Dosage: 20 mg/kg Administration: I.p.; every 2 days for 40 days Result: Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis.
References	[1]. Puxeddu M, et al. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. Eur J Med Chem. 2020 Jan 1;185:111828.

Molecular Formula	C₂₆H₂₅N₃O₄
Molecular Weight	443.49

Anticancer agent 48

Use of Anticancer agent 48

Names

Anticancer agent 48 Biological Activity

Chemical & Physical Properties