Isoallolithocholic acid-d2

Modify Date: 2024-01-13 21:18:13

Isoallolithocholic acid-d2 structure	Common Name	Isoallolithocholic acid-d2
	CAS Number	2410277-69-7	Molecular Weight	378.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₈D₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Isoallolithocholic acid-d2

Isoallolithocholic acid-d2 is the deuterium labeled Isoallolithocholic acid. Alloisolithocholic acid (AILCA) activates large-conductance calcium-activated potassium (BK) channels with an EC50 value of 44.21 μM in Xenopus oocytes[1][2].

Name	Isoallolithocholic acid-d2

Description	Isoallolithocholic acid-d2 is the deuterium labeled Isoallolithocholic acid. Alloisolithocholic acid (AILCA) activates large-conductance calcium-activated potassium (BK) channels with an EC50 value of 44.21 μM in Xenopus oocytes[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bukiya AN, et al. Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels. J Lipid Res. 2008 Nov;49(11):2441-51.

Molecular Formula	C₂₄H₃₈D₂O₃
Molecular Weight	378.58

Isoallolithocholic acid-d2

Use of Isoallolithocholic acid-d2

Names

Isoallolithocholic acid-d2 Biological Activity

Chemical & Physical Properties