TLR8 agonist 2

Modify Date: 2024-01-12 15:13:52

TLR8 agonist 2 structure	Common Name	TLR8 agonist 2
	CAS Number	2412937-64-3	Molecular Weight	326.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₂N₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TLR8 agonist 2

TLR8 agonist 2 is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 shows less active against human TLR7 (EC50 of 33.33 μM)[1].

Name	TLR8 agonist 2

Description	TLR8 agonist 2 is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 shows less active against human TLR7 (EC50 of 33.33 μM)[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
Target	TLR8:3 nM (EC50) TLR7:33.33 μM (EC50)
In Vitro	TLR8 agonist 2 (Example 1) increases the levels of TNF-α, IL-12p40, IFN-γ, and IFN-α with EC50 values 105 nM, 26 nM, 29 nM, and 2800 nM, respectively, in human peripheral blood mononuclear cells (hPBMC)[1].
In Vivo	The pharmacokinetic related parameters of TLR8 agonist 2 (Example 1) in mice administered with the intravenous administration of 1 mg/kg and the oral administration of 5 mg/kg are detected. The T1/2 of TLR8 agonist 2 are 0.25 h (1 mg/kg i.v.) and 0.5 h (5 mg/kg p.o.), the AUClast are 450 ng/mLhr (i.v.) and 624 ng/mLhr (p.o.). And for oral administration, the bioavailability (%F) is 27.7%[1]
References	[1]. Zhe Cai, et al. Tlr8 agonist. WO2020057604A1.

Molecular Formula	C₁₆H₂₂N₈
Molecular Weight	326.40

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TLR8 agonist 2
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
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