2412937-64-3
2412937-64-3 structure
- Name: TLR8 agonist 2
- Chemical Name: TLR8 agonist 2
- CAS Number: 2412937-64-3
- Molecular Formula: C16H22N8
- Molecular Weight: 326.40
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2021-09-12 10:26:05
- Modify Date: 2024-01-12 15:13:52
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TLR8 agonist 2 is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 shows less active against human TLR7 (EC50 of 33.33 μM)[1].
| Name | TLR8 agonist 2 |
|---|
| Description | TLR8 agonist 2 is a potent and selective TLR8 agonist with an EC50 of 3 nM for human TLR8. TLR8 agonist 2 shows less active against human TLR7 (EC50 of 33.33 μM)[1]. |
|---|---|
| Related Catalog | |
| Target |
TLR8:3 nM (EC50) TLR7:33.33 μM (EC50) |
| In Vitro | TLR8 agonist 2 (Example 1) increases the levels of TNF-α, IL-12p40, IFN-γ, and IFN-α with EC50 values 105 nM, 26 nM, 29 nM, and 2800 nM, respectively, in human peripheral blood mononuclear cells (hPBMC)[1]. |
| In Vivo | The pharmacokinetic related parameters of TLR8 agonist 2 (Example 1) in mice administered with the intravenous administration of 1 mg/kg and the oral administration of 5 mg/kg are detected. The T1/2 of TLR8 agonist 2 are 0.25 h (1 mg/kg i.v.) and 0.5 h (5 mg/kg p.o.), the AUClast are 450 ng/mL*hr (i.v.) and 624 ng/mL*hr (p.o.). And for oral administration, the bioavailability (%F) is 27.7%[1] |
| References |
| Molecular Formula | C16H22N8 |
|---|---|
| Molecular Weight | 326.40 |