GABAA receptor modulator-2

Modify Date: 2024-01-12 22:32:09

GABAA receptor modulator-2 structure	Common Name	GABAA receptor modulator-2
	CAS Number	2413850-54-9	Molecular Weight	459.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₂FN₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GABAA receptor modulator-2

GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].

Name	GABAA receptor modulator-2

Description	GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	Ki: 4.1 nM (hα5)[1]
In Vivo	GABAA receptor modulator-2 (Compound 20) (0-10 mg/kg) produces a dose-dependent reversal of the PCP-induced cognitive deficit in the rat subPCP NOR test[1].
References	[1]. Szabó G, et al. Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABAA Receptor Negative Allosteric Modulators. J Med Chem. 2022 Jun 9;65(11):7876-7895.

Molecular Formula	C₂₂H₂₂FN₃O₅S
Molecular Weight	459.49