2413850-54-9

2413850-54-9 structure

Name: GABAA receptor modulator-2
Chemical Name: GABAA receptor modulator-2
CAS Number: 2413850-54-9
Molecular Formula: C₂₂H₂₂FN₃O₅S
Molecular Weight: 459.49
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2022-06-26 07:51:36
Modify Date: 2024-01-12 22:32:09
GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].

Name	GABAA receptor modulator-2

Description	GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	Ki: 4.1 nM (hα5)[1]
In Vivo	GABAA receptor modulator-2 (Compound 20) (0-10 mg/kg) produces a dose-dependent reversal of the PCP-induced cognitive deficit in the rat subPCP NOR test[1].
References	[1]. Szabó G, et al. Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABAA Receptor Negative Allosteric Modulators. J Med Chem. 2022 Jun 9;65(11):7876-7895.

Molecular Formula	C₂₂H₂₂FN₃O₅S
Molecular Weight	459.49