Thalidomide-O-C5-NH2 hydrochloride

Modify Date: 2024-01-10 19:14:56

Thalidomide-O-C5-NH2 hydrochloride Structure
Thalidomide-O-C5-NH2 hydrochloride structure
Common Name Thalidomide-O-C5-NH2 hydrochloride
CAS Number 2419145-66-5 Molecular Weight 395.84
Density N/A Boiling Point N/A
Molecular Formula C18H22ClN3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-O-C5-NH2 hydrochloride


Thalidomide-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

 Names

Name Thalidomide-O-C5-NH2 hydrochloride

 Thalidomide-O-C5-NH2 hydrochloride Biological Activity

Description Thalidomide-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Molecular Formula C18H22ClN3O5
Molecular Weight 395.84

 Safety Information

Hazard Codes Xi
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