BRD4 Inhibitor-18
Modify Date: 2024-01-04 14:28:26
BRD4 Inhibitor-18 structure
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Common Name | BRD4 Inhibitor-18 | ||
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| CAS Number | 2451219-73-9 | Molecular Weight | 496.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H26ClN3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD4 Inhibitor-18BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1]. |
| Name | BRD4 Inhibitor-18 |
|---|
| Description | BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1]. |
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| Related Catalog | |
| Target |
IC50: 110 nM (BRD4)[1] |
| In Vitro | BRD4 Inhibitor-18 (compound 13f) (0-10 μM; 72 hours) can suppress the proliferation of HL-60 and MV-41 cells[1]. BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) significantly arrests MV-4-11 cells in G1 phase in a dose-dependent manner[1]. BRD4 Inhibitor-18 (0.5 and 5 μM; 12 hours) effectively induces apoptosis of MV-4-11 cells in a dose-dependent manner[1]. BRD4 Inhibitor-18 (0.5 and 5 μM; 4 hours) inhibits the expression of c-Myc protein in a dose-dependent manner[1]. Cell Proliferation Assay Cell Line: HL-60 and MV-4-11[1] Concentration: 0-10 μM Incubation Time: 72 hours Result: Suppressed the proliferation of HL-60 and MV-41 cells with IC50s of 5.52 μM and 0.42 μM. Cell Cycle Analysis Cell Line: MV-4-11 cells[1] Concentration: 0.5 and 5 μM Incubation Time: 12 hours Result: Significantly arrested MV-4-11 cells in G1 phase in a dose-dependent manner. Apoptosis Analysis Cell Line: MV-4-11 cells[1] Concentration: 0.5 and 5 μM Incubation Time: 12 hours Result: Effectively induced apoptosis of MV-4-11 cells in a dose-dependent manner. Western Blot Analysis Cell Line: MV-4-11 cells[1] Concentration: 0.5 and 5 μM Incubation Time: 4 hours Result: Inhibited the expression of c-Myc protein in a dose-dependent manner. |
| References |
| Molecular Formula | C26H26ClN3O3S |
|---|---|
| Molecular Weight | 496.02 |