Anticancer agent 71
Modify Date: 2024-01-07 21:33:47
Anticancer agent 71 structure
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Common Name | Anticancer agent 71 | ||
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| CAS Number | 2453228-45-8 | Molecular Weight | 407.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H13ClF3N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Anticancer agent 71Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1]. |
| Name | Anticancer agent 71 |
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| Description | Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1]. |
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| Related Catalog | |
| In Vitro | Anticancer agent 71 (Compound 4b) (0.1-50 μM, 24 hours; SW480 and PC3 cells) increases the cytotoxicity and exerts potent antitumor activities against SW480 and PC3 cells[1]. Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours; SW480 cells) induces a significant G2/M phase arrest[1]. Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours) induces apoptosis in SW480 cells by upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression[1]. Cell Cytotoxicity Assay[1] Cell Line: SW480 and PC3 cells Concentration: 0.1, 1, 12.5, 25 and 50 μM Incubation Time: 24 hours Result: Inhibited with IC50 values of 11.08 and 17.39 μM for SW480 and PC3 cells, respectively. Cell Cycle Analysis[1] Cell Line: SW480 cells Concentration: 11.08 μM Incubation Time: 24 hours Result: The cell population percent at G2/M phase increased to 45.3%. Apoptosis Analysis[1] Cell Line: SW480 cells Concentration: 11.08 μM Incubation Time: 24 hours Result: The percentage of cells in early and late apoptosis was recorded as 5.69% and 3.52%, respectively. Western Blot Analysis[1] Cell Line: SW480 cells Concentration: 11.08 μM Incubation Time: 24 hours Result: The expression of antiapoptotic protein Bcl-2 decreased and the expression of Pro apoptotic Bax increased. |
| References |
| Molecular Formula | C18H13ClF3N5O |
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| Molecular Weight | 407.78 |