HDAC-IN-40

Modify Date: 2024-01-14 10:07:18

HDAC-IN-40 structure	Common Name	HDAC-IN-40
	CAS Number	2463198-51-6	Molecular Weight	326.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₂₂N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC-IN-40

HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects[1].

Name	HDAC-IN-40

Description	HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC2:60 nM (Ki) HDAC6:30 nM (Ki) HDAC4:49200 μM (Ki) HDAC8:5690 nM (Ki)
In Vitro	HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively[1]. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR[1]. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1].
References	[1]. Yodita Asfaha, et al. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem. 2020 Jan 1;28(1):115108.

Molecular Formula	C₁₅H₂₂N₂O₆
Molecular Weight	326.34

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HDAC-IN-40
Price: Click To Check
Purity: 99.01%
Delivery: 10 Day
Contact: Yang
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