SIRT6 activator CL5D
Modify Date: 2024-04-03 15:23:10
SIRT6 activator CL5D structure
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Common Name | SIRT6 activator CL5D | ||
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| CAS Number | 2488745-53-3 | Molecular Weight | 731.565 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H11Cl7N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SIRT6 activator CL5DSIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.CL5D demonstrate competitive inhibition with Ki of 13.4 uM.CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells. |
| Name | SIRT6 activator CL5D |
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| Description | SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.CL5D demonstrate competitive inhibition with Ki of 13.4 uM.CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells. |
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| References | 1. Mark A Klein, et al. J Biol Chem. 2020 Jan 31;295(5):1385-1399. |
| Molecular Formula | C29H11Cl7N2O6 |
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| Molecular Weight | 731.565 |